1-Methylimidazole → N3-[2-(2-nitrophenyl)propoxycarbonyl]-N-methyl imidazolium chloride

Participants

Reaction Steps

1.07 ml 2-(2-nitrophenyl)propoxycarbonyl chloride (1) (4.4 mmol) are slowly added dropwise to a solution of 1.24 ml N-methylimidazole (14.7 mmol) in 40 ml dichloromethane at 0° C. over molecular sieve 4 Å. Following stirring for 30 minutes in an ice bath this solution is used directly for acylation with 1.2 equivalents of the 5′-O-protected nucleoside building blocks.

Provenance & Evidence