反应详情

3.1 g (0.02 mol) of 3-chloro-2-methylanisole are heated in 20 ml of 50% sulphuric acid for 18 hours with reflux. After cooling, the reaction mixture is extracted three times with dichloromethane, dried over sodium sulphate and concentrated to dryness under reduced pressure. 3-Chloro-2-methylphenol is obtained as a solid (2.9 g, content by HPLC: 11.7%, 12% of theory).

1. temperaturewith reflux
2. temperatureAfter cooling
3. extractionthe reaction mixture is extracted three times with dichloromethane
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated to dryness under reduced pressure