HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Cyclohexadiene → 1-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Cyclohexadiene | HCID 12343 | — |
| Reactant | N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester | HCID 53791828 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester | HCID 17992581 | — |
Reaction Steps
N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester is dissolved in absolute alcohol at 0° C. in an ultrasound bath. Palladium on carbon (10%) is added. The hydrogen source, 1,4-cyclohexadiene, is added, and ultrasound is commenced for eight minutes. The slurry is then filtered through a bed of Celite with ethyl alcohol. The solvent is removed by rotary evaporation to yield 1-aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04766246 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-53af94323f0249e79cb917e1a1115caf |
| Source note | uspto-grants-1988_08 |