Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 13273327 | HCID 13273327 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 78347-69-0 | HCID 86738809 | — |
Reaction Steps
A solution of 2 mmole of beta-difluoromethyl beta-alanine in 15 ml of dichloromethane is treated with 2 mmole of thionyl chloride at 25° C. for one hour after which 20 ml of ethanol is added. The solution is stirred at 25° C. for one hour and concentrated to afford 3-amino-3-difluoromethylpropionic acid ethyl ester hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04375477 |
|---|
| Source dataset | uspto-grants-1983_03 |
|---|
| ORD ID | ord-9cef3e6946324cbabd35f3ba3eb8b3be |
|---|
| Source note | uspto-grants-1983_03 |
|---|
