4,4-Dimethyl-2-(2-methoxyphenyl)oxazoline → 2-(3,5-Dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)-4,4-dimethyl-2-oxazoline
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4](OC)[C:3]=1[C:11]1[O:12][CH2:13][C:14]([CH3:17])([CH3:16])[N:15]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([Mg]Br)=[CH:21][CH:20]=1.COC1C=CC=CC=1C1OCC(C)(C)N=1.COC1C=CC=CC=1[Mg]Br>>[Cl:1][C:2]1[C:3]([C:11]2[O:12][CH2:13][C:14]([CH3:17])([CH3:16])[N:15]=2)=[C:4]([C:22]2[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1参加物
5
実験手順
By substituting equimolar amounts of 2-(2,4-dichloro-6-methoxyphenyl)-4,4-dimethyl-2-oxazoline and 4-fluorophenylmagnesium bromide for 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline and 2-methoxyphenylmagnesium bromide, the title compound was prepared following the procedure of Example 17, Step A, (85%), mp 93°-95° C.
出典と根拠
- ORDレコード
- ord-09d54cf28451475dad5681e4f68fc2c6
- 出典データセット
- uspto-grants-1983_03
- 特許番号
- US04375475
反応ノート
読み込み中…