HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Methylaminomethyl-4-thiazolylmethylthio)ethylamine → N-Desmethylnizatidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Methylaminomethyl-4-thiazolylmethylthio)ethylamine | HCID 15053477 | — |
| Reactant | 1-Methyl-2-methylsulfanyl-3-nitroaziridine | HCID 19370617 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Desmethylnizatidine | HCID 133957 | — |
Reaction Steps
Following the above procedure, 2-([2-(methylaminomethyl)-4-thiazolyl]methylthio)ethylamine and N-methyl-1-methylthio-2-nitroethyleneamine were reacted in water solution. The reaction was worked up and the product isolated by the above procedure to yield N-methyl-N'-2-([2-(methylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine melting at 105°-107° C. after recrystallization from acetonitrile followed by recrystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04375547 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-65883af12c57410eb399121e809c1986 |
| Source note | uspto-grants-1983_03 |