4-Aminophenol → HCID 23677017, compound

Participants

Reaction Steps

6.6 g (0.06 mol) of p-aminophenol in 4.0 g (0.06 mol) potassium hydroxide (purity 85%) and 80 ml of dimethylsulfoxide was heated under stirring. The water generated was distilled off under reduced pressure to obtain the potassium p-aminophenolate. To the solution, which was allowed to be cooled to room temperature, was added a solution of 10.9 g (0.06 mol) of 6-fluoro-2-chloroquinoxaline dissolved in 60 ml of dioxane. The mixture was reacted at 50°-60° C. for 3 hours. After the reaction was over, the reaction solution was poured onto ice and the separated solid was filtered off, and washed with 5% aqueous solution of sodium hydroxide and then washed with water. The substance thus obtained was recrystallized from ethanol to yield 8.2 g (yield 54%) of the intended compound (Compound No. 4) having a melting point of 174°-175.5° C. as light-yellow crystals.

Provenance & Evidence