Aniline → Indole

Participants

Reaction Steps

Reaction was carried out in the same manner as described in Example 1 except that granular activated carbon was used in place of the Pd-C catalyst, 6.1 g (0.1 mole) of monoethanolamine or 9.3 g (0.1 mole) of diethanolamine was used as the ethanolamine, and the reaction temperature was raised to 400° C. When monoethanolamine was used, 2.7 g of indole was obtained in a 23.5% yield based on the aniline. Similarly, when diethanolamine was used, 2.9 g of indole was obtained in a 24.5% yield based on the aniline.

Provenance & Evidence