反应详情

To a solution of 9.42 g. (0.1 mole) of 2-aminopyridine in 50 ml. of methylene chloride was added dropwise 4.0 ml. (0.05 mole) of chloroacetyl chloride in 20 ml. of the same solvent, keeping the reaction temperature at -20° to -10° C. for one hour. After stirring at room temperature for 10 hours, 50 ml. of water was added and the organic layer separated. The organic solution was washed with water and a brine solution and was dried over magnesium sulfate. Removal of the solvent in vacuo gave 6.64 g. (78%), m.p. 114°-117° C., of the desired product.

1. customat -20° to -10° C.
2. customfor one hour
3. customthe organic layer separated
4. washThe organic solution was washed with water
5. dry with materiala brine solution and was dried over magnesium sulfate
6. customRemoval of the solvent in vacuo
7. customgave 6.64 g