Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-methyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | HCID 27290 | — |
| Reactant | 2-Chloro-N-pyridin-2-yl-acetamide | HCID 289435 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Piroxicam | HCID 54676228 | — |
Reaction Steps
To a solution of 590 mg. (3 mmole) of N-methylsaccharin and 1.02 g. (6 mmole) of N-(2-pyridyl)chloroacetamide in 3 ml. of dimethylformamide at 40° C. was added 250 mg. (10.3 mmole) of 99% sodium hydride portionwise over a period of one hour. The reaction mixture was allowed to stir at 40° C. for 2.5 hours and was then added to 100 ml. of 5% hydrochloric acid solution and 300 ml. of ice. The precipitate was filtered and dried to give 24 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04376204 |
|---|
| Source dataset | uspto-grants-1983_03 |
|---|
| ORD ID | ord-823a908058fe4a159dd1d2d1c6d28509 |
|---|
| Source note | uspto-grants-1983_03 |
|---|
