HCID 15916793, compound → HCID 15916795, compound

Participants

Reaction Steps

Dissolve 4.9 g of the product of Step C in 30 ml of 1,2-dichloroethane and 5.6 g of methane sulfonic acid (98%). Reflux the mixture for one (1) hour then remove the solvent in vacuo. Add 80 ml of ice-water then adjust to an alkaline pH with 10% sodium hydroxide solution. Extract with methylene chloride, dry the extract over sodium sulfate and concentrate to an oil which crystallizes from petroleum ether M.P. 69°-71° C.

Provenance & Evidence