3-Chloropropionyl chloride → HCID 20507193, compound

Participants

Reaction Steps

6.0 g (29.6 millimoles) of 6-(p-aminophenyl)-5-methyl-4,5-dihydropyridaz-3-one and 4.1 g (32.3 millimoles) of 3-chloropropionyl chloride are stirred with 100 ml of absolute toluene for 4 hours at 80° C. The product is filtered off at 10° C., washed with water and dried under reduced pressure at 50° C. 5.8 g (67% of theory) of 6-[p-(3-chloropropionylamino)-phenyl]-5-methyl-4,5-dihydropyridaz-3-one are obtained as beige crystals which, after recrystallization from methanol, melt, with decomposition, at 221°-223° C.

Provenance & Evidence