1-(Bromomethyl)-3-phenoxybenzene → 3-Phenoxybenzyl alpha-fluoro-alpha-isopropylphenylacetate

Participants

Reaction Steps

This compound was prepared from 3-phenoxybenzyl bromide and α-fluoro-α-isopropylphenylacetic acid following the method used in Example 2 Method B for the preparation of α-fluoro-3-phenoxybenzyl α-isopropyl-4-chlorophenylacetate. The product, a colourless oil, was characterised by pmr spectroscopy. Chemical shift ppm (solvent CDCl3): 0.69(3H, d, J=6 Hz, CH3); 1.05 (3H, d of d, J=6 Hz and J=2 Hz, CH3); 2.34(1H, m, CH(CH3)2); 3.27 (1H, d, J=10 Hz, CH); 7.17(1H, d of d, J=56 Hz and J=2 Hz, CHF) and c. 7.20(14H, m, aromatic protons).

Provenance & Evidence