2-(4-Methoxyphenyl)-3-methylbutanoic acid → alpha-Fluoro-3-phenoxybenzyl alpha-isopropyl-(4-methoxyphenyl)acetate

Participants

Reaction Steps

This compound was prepared from α-isopropyl-(4-methoxyphenyl)acetic acid and α-fluoro-3-phenoxybenzylbromide following the procedure described in Example 2 Method B. The product, a colourless oil, was characterised by pmr spectroscopy. Chemical shift δppm (solvent CDCl3): 0.72 (3H, d, J=6 Hz, CH3); 1.06 (3H, d of d, J=6 Hz and J=2 Hz, CH3); about 2.25 (1H, m, --CH(CH3)2); 3.17 (1H, d, J=10 Hz, CH); 3.76 (3H, s, CH3O); 7.18 (1H, d of d, J=56 Hz and J=2 Hz, CHF); about 7.2 (13H, m, aromatic protons).

Provenance & Evidence