反应详情

94.9 g of (4-methoxy-3,5-dimethyl-2-pyridyl)methyl acetate are dissolved in 570 ml of ethanol. 285 ml of 3N sodium hydroxide solution are then added dropwise thereto at 0° and the mixture is stirred at room temperature for 3 hours. The ethanol is subsequently removed in vacuo, whereupon the residual aqueous solution is extracted three times with 300 ml of methylene chloride. The organic extracts are dried over sodium sulphate and evaporated in vacuo. The residue is crystallized from petroleum ether and there is obtained 4-methoxy-3,5-dimethyl-2-pyridylmethanol of melting point 49°-51°.

1. customThe ethanol is subsequently removed in vacuo, whereupon the residual aqueous solution
2. extractionis extracted three times with 300 ml of methylene chloride
3. dry with materialThe organic extracts are dried over sodium sulphate
4. customevaporated in vacuo
5. customThe residue is crystallized from petroleum ether