HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylaminoethyl chloride → 5-(o-chlorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylaminoethyl chloride | HCID 13364 | — |
| Reactant | 5-(o-chlorophenyl)-1-(2-diethylaminoethyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one | HCID 20506148 | — |
| Reactant | 5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-7-nitro-2H-1,4-benzodiazepin-2-one | HCID 20506156 | — |
| Solvent | Diethylether hexane | HCID 21584099 | — |
| Product | 5-(o-chlorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one | HCID 20506168 | — |
Reaction Steps
From 25 g (0.073 mol) of 5-(o-chlorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one and 2-diethylaminoethyl chloride there is obtained, in analogy to the details in paragraph (c) of Example 1, with a reaction period of 60 hours, 5-(o-chlorophenyl)-1,3-dihyro-1-(2-diethylaminoethyl)-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one of melting point 109° (ether/n-hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377522 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-6b67598530524fdabc37056985f36d87 |
| Source note | uspto-grants-1983_03 |