7-(butylamino)-9-chloro-5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-one → benzyl 9-chloro-5-(o-fluorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepine-7-carbamate

HRID 354769Notes

Reaction equation

HRID 354769 reaction equation
C(NC1C=C(Cl)C2N(C)C(=O)C(C)(C)N=C(C3C=CC=CC=3F)C=2C=1)CCC.[Cl:29][C:30]1[C:40]2[N:39]([CH3:41])[C:38](=[O:42])[C:37]([CH3:44])([CH3:43])[N:36]=[C:35]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=3[F:51])[C:34]=2[CH:33]=[C:32]([N:52](CC)[C:53]([O:55][CH2:56][C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)=[O:54])[CH:31]=1>CCCCCC>[Cl:29][C:30]1[C:40]2[N:39]([CH3:41])[C:38](=[O:42])[C:37]([CH3:44])([CH3:43])[N:36]=[C:35]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=3[F:51])[C:34]=2[CH:33]=[C:32]([NH:52][C:53]([O:55][CH2:56][C:57]2[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=2)=[O:54])[CH:31]=1

Participants

4

Reactant 2

HCID 205061547-(butylamino)-9-chloro-5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-oneHCID 20506199benzyl 9-chloro-N-ethyl-5-(o-fluorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepine-7-carbamate

Product 1

HCID 20506189benzyl 9-chloro-5-(o-fluorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepine-7-carbamate

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

From 9.6 g (0.02 mol) of benzyl 9-chloro-5-(o-fluorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepine-7-carbamate there is obtained, in analogy to the details in paragraph (b) of Example 39, benzyl 9-chloro-N-ethyl-5-(o-fluorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepine-7-carbamate of melting point 125°-127° (hexane).

Sources & evidence

ORD record
ord-49f3cc75cb774058a2813bbd876f5186
Source dataset
uspto-grants-1983_03
Patent number
US04377522

Reaction notes

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