HRID354769

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCNc1cc(Cl)c2c(c1)C(c1ccccc1F)=NC(C)(C)C(=O)N2C

HCID20506154

未命名化合物

结构：CCN(C(=O)OCc1ccccc1)c1cc(Cl)c2c(c1)C(c1ccccc1F)=NC(C)(C)C(=O)N2C

HCID20506199

未命名化合物

PRODUCTS

生成物

结构：CN1C(=O)C(C)(C)N=C(c2ccccc2F)c2cc(NC(=O)OCc3ccccc3)cc(Cl)c21

HCID20506189

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8058

n-Hexane

C6H14

PROCEDURE

实验过程

From 9.6 g (0.02 mol) of benzyl 9-chloro-5-(o-fluorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepine-7-carbamate there is obtained, in analogy to the details in paragraph (b) of Example 39, benzyl 9-chloro-N-ethyl-5-(o-fluorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepine-7-carbamate of melting point 125°-127° (hexane).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-49f3cc75cb774058a2813bbd876f5186
来源数据集: uspto-grants-1983_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04377522
来源说明: uspto-grants-1983_03

反应 SMILES

C(NC1C=C(Cl)C2N(C)C(=O)C(C)(C)N=C(C3C=CC=CC=3F)C=2C=1)CCC.[Cl:29][C:30]1[C:40]2[N:39]([CH3:41])[C:38](=[O:42])[C:37]([CH3:44])([CH3:43])[N:36]=[C:35]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=3[F:51])[C:34]=2[CH:33]=[C:32]([N:52](CC)[C:53]([O:55][CH2:56][C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)=[O:54])[CH:31]=1>CCCCCC>[Cl:29][C:30]1[C:40]2[N:39]([CH3:41])[C:38](=[O:42])[C:37]([CH3:44])([CH3:43])[N:36]=[C:35]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=3[F:51])[C:34]=2[CH:33]=[C:32]([NH:52][C:53]([O:55][CH2:56][C:57]2[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=2)=[O:54])[CH:31]=1