Piperidine → HCID 12834693, compound

Participants

Reaction Steps

5.0 gm (0.015 mol) of 2-chloro-5-(3-chloropropionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 4.3 gm (0.05 mol) of piperidine were refluxed in 100 ml of dioxane for 1 hour. The reaction mixture was evaporated in vacuo, the residue was dissolved in dilute acetic acid, and the solution was filtered after addition of activated charcoal. The filtrate was made alkaline with ammonia and extracted with chloroform. The chloroform solution was evaporated in vacuo, and the residue was crystallized from isopropanol and recrystallized from methanol. 2.9 gm of the title compound, m.p. 170°-172° C., were obtained.

Provenance & Evidence