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Triethylamine → 5-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 12834682 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 12834710 | — |
反応手順
5.0 gm (0.017 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2.0 gm (0.02 mol) of triethylamine were refluxed in 250 ml of ethanol for 30 minutes. Subsequently, the reaction mixture was evaporated in vacuo, and the residue was stirred with water. After suction-filtering and drying, 5-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one was obtained with a quantitative yield. Recrystallization from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04377576 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-a53088ad3e5d4f2db3eefbeecda9ce35 |
| 出典メモ | uspto-grants-1983_03 |