1-(2-Furoyl)piperazine → 2-[4-(2-Furoyl)piperazine-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride

HRID 354809Notes

Reaction equation

HRID 354809 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=2)[N:3]=1.[O:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:22]>C(O)CC(C)C>[ClH:1].[O:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:21]([N:23]1[CH2:24][CH2:25][N:26]([C:2]2[N:11]=[C:10]([NH2:12])[C:9]3[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=3)[N:3]=2)[CH2:27][CH2:28]1)=[O:22]

Participants

4

Reactant 2

HCID 5502061-(2-Furoyl)piperazineHCID 129200072,6-Dichloro-7-methoxyquinazolin-4-amine

Product 1

HCID 205063992-[4-(2-Furoyl)piperazine-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochlorideYield 79%

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

The title compound was prepared similarly by refluxing 2,6-dichloro-4-amino-7-methoxyquinazoline and 1-(2-furoyl)piperazine in isoamyl alcohol, M.P. 229°-31° C., 79% yield.

Sources & evidence

ORD record
ord-fdea479b018942c8a00102b5f5eb8e71
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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