Thiazolidine → HCID 20506426, compound

HRID 354816Notes

Reaction equation

HRID 354816 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[S:17]1[CH2:21][CH2:20][NH:19][CH2:18]1>ClC1C=CC=CC=1>[ClH:16].[S:17]1[CH2:21][CH2:20][N:19]([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=2)[CH2:18]1

Participants

4

Reactant 2

HCID 10444ThiazolidineHCID 129200082-Chloro-4-amino-7,8-dimethoxyquinazoline

Product 1

HCID 20506426HCID 20506426, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of 4.8 g. (0.02 mole) of 4-amino-2-chloro-7,8-dimethoxyquinazoline and 4.5 g. (0.05 mole) of thiazolidine in 50 ml. of chlorobenzene is heated at reflux for 18 hours, cooled to room temperature and the precipitate collected by filtration to give the title compound which was purified by recrystallization.

Workup

  1. additionA mixture of 4.8 g
  2. temperatureat reflux for 18 hours
  3. filtrationthe precipitate collected by filtration

Sources & evidence

ORD record
ord-2096d81be9bf4a5f8997356a1ec9f56c
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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