Hydrochloric Acid → 2-[[(2-Aminoethyl)dithio]methyl]-3,5-dimethyl-1-[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium chloride

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Reaction Steps

3.53 g of 2-[[(3,5-dimethyl-2-pyridyl)methyl]sulphinyl]-5 -(trifluoromethyl)benzimidazole are dissolved in 50 ml of tetrahydrofuran and treated with 0.77 g of cysteamine. 40 ml of 3N hydrochloric acid are added thereto at an internal temperature of 40°. The mixture is stirred at 40° overnight and subseguently evaporated in vacuo. The residue is crystallized from tert.butyl methyl ether/ether. There is obtained 2-[[(2-aminoethyl)dithio]methyl]-3,5-dimethyl-1 -[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium chloride of melting point 115°-120°.

Provenance & Evidence