関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Dimethyl methoxymethylenemalonate | HCID 90770 | — |
| 反応物 | 4-Amino-6-(2-ethylbutyramido)quinazoline | HCID 13060462 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate | HCID 13060503 | 56.1% |
反応手順
A mixture of 4-amino-6-(2-ethylbutyramido)quinazoline (5.58 g), dimethyl methoxymethylenepropanedioate (5.62 g) and N,N-dimethylformamide (22 ml) was stirred at 100° C. for 1.5 hours. After cooling to ambient temperature, water (90 ml) was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (4.85 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04377580 |
|---|
| 出典データセット | uspto-grants-1983_03 |
|---|
| ORD ID | ord-6ac3ed39b7914879bb8f583030772233 |
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| 出典メモ | uspto-grants-1983_03 |
|---|
