HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 354891Generated: October 25, 2026
Dimethyl[[6-(3-cyclopentylpropionamido)-4-quinazolinylamino]methylene]propanedioate → methyl 4-oxo-10-(3-cyclopentylpropionamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate
https://huagongshe.com/reaction/354891
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl[[6-(3-cyclopentylpropionamido)-4-quinazolinylamino]methylene]propanedioate | HCID 13060507 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | methyl 4-oxo-10-(3-cyclopentylpropionamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate | HCID 13060558 | 70.5% |
Reaction Steps
A mixture of dimethyl [[6-(3-cyclopentylpropionamido)-4-quinazolinylamino]methylene]propanedioate (6.9 g) in diphenyl ether (53 ml) was stirred at 255° C. for 15 minutes and cooled to ambient temperature. The resulting solid was collected, washed with hexane and dried. There was obtained methyl 4-oxo-10-(3-cyclopentylpropionamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (4.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04377580 |
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| Source dataset | uspto-grants-1983_03 |
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| ORD ID | ord-f077d5dee8074588b39bb6bb6c8adc6a |
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| Source note | uspto-grants-1983_03 |
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