HCID 14157299, compound → HCID 14157300, compound

Participants

Reaction Steps

257.4 g of N-(1'-methoxycarbonylethyl)-N-methoxyacetyl-2-methyl-6-nitroaniline are dissolved in 2.6 liters of anhydrous methanol and the solution is hydrogenated for 26 hours at 20°-25° C. and under normal pressure in the presence of 26 g of raney nickel (uptake of H2 : 56.2 liters=100% of theory). The catalyst is then removed by filtration, the filtrate is concentrated, and the oily residue is crystallised by adding diethyl ether. Yield: 170.8 g of compound 2 with a melting point of 86°-88° C.

Provenance & Evidence