反应详情

To a stirred mixture of 21 parts of 5-chloro-2-cyclohexyl-1H-benzimidazole-1-propanol in 225 parts of trichloromethane are added dropwise 40 parts of sulfinyl chloride (exothermic reaction). Upon completion, stirring is continued for 2 hours at reflux temperature. The reaction mixture is evaporated and the residue is dissolved in boiling water. The solution is treated with activated charcoal. The latter is filtered off till a clear filtrate is obtained. After cooling in an ice-bath, the precipitated product is filtered off and dried, yielding 5-chloro-1-(3-chloropropyl)-2-cyclohexyl-1H-benzimidazole hydrochloride; mp. 211.7° C.

1. temperatureat reflux temperature
2. customThe reaction mixture is evaporated
3. dissolutionthe residue is dissolved
4. additionThe solution is treated with activated charcoal
5. filtrationThe latter is filtered off till a clear filtrate
6. customis obtained
7. temperatureAfter cooling in an ice-bath
8. filtrationthe precipitated product is filtered off
9. customdried