反应详情

To a stirred mixture of 26 parts of 3-{[2-nitro-4-(trifluoromethyl)phenyl]amino}-1-propanol and 150 parts of trichloromethane are added dropwise 40 parts of sulfinyl chloride. Upon completion, stirring is continued overnight at reflux temperature. The reaction mixture is evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (95:5) as eluent. The pure fractions are collected and the eluent is evaporated, yielding N-(3-chloropropyl)-2-nitro-4-(trifluoromethyl)benzenamine as a residue.

1. temperatureat reflux temperature
2. customThe reaction mixture is evaporated
3. customThe residue is purified by column-chromatography over silica gel using
4. additiona mixture of trichloromethane and methanol (95:5) as eluent
5. customThe pure fractions are collected
6. customthe eluent is evaporated