4-(diphenylmethyl) N-(2-nitrophenyl)-1-piperazinepropanamine hydrochloride → N-(2-aminophenyl)-4-(diphenylmethyl)-1-piperazinepropanamine hydrochloride

Participants

Reaction Steps

A mixture of 15 parts of 4-(diphenylmethyl) N-(2-nitrophenyl)-1-piperazinepropanamine hydrochloride in 160 parts of methanol is hydrogenated at normal pressure and at room temperature with 5 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off over hyflo and the filtrate is evaporated. The solid residue is crystallized from a mixture of 2-propanol and 2,2'-oxybispropane. The product is filtered off and dried, yielding N-(2-aminophenyl)-4-(diphenylmethyl)-1-piperazinepropanamine hydrochloride; mp. 223.1° C.

Provenance & Evidence