反应详情

A mixture of 4.9 parts of 1-(3-chloropropyl)-1H-benzimidazole, 5.76 parts of 1-[bis(4-fluorophenyl)methyl]piperazine, 5.3 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 20 hours with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is crystallized from a mixture of 4-methyl-2-pentanone and 2,2'-oxybispropane. The product is filtered off and dried, yielding 1-[3-{4-[bis(4-fluorophenyl)methyl]-1-piperazinyl}propyl]-1H-benzimidazole hydrate; mp. 108.4° C.

1. temperatureThe reaction mixture is cooled
2. customthe layers are separated
3. customThe organic phase is dried
4. filtrationfiltered
5. customevaporated
6. customThe residue is crystallized from a mixture of 4-methyl-2-pentanone and 2,2'-oxybispropane
7. filtrationThe product is filtered off
8. customdried