反应详情

A mixture of 4.37 parts of N-(2-aminophenyl)-4-(diphenylmethyl)-1-piperazinepropanamine hydrochloride, 38 parts of carbon disulfide, 2 parts of sodium carbonate and 40 parts of ethanol is stirred and refluxed for 20 hours. The reaction mixture is evaporated and water is added to the residue. The precipitated product is filtered off, washed with water and dissolved in trichloromethane. The solution is dried, filtered and evaporated. The residue is crystallized from 4-methyl-2-pentanone, yielding 1-{3-[4-(diphenylmethyl)-1-piperazinyl]propyl}-1H-benzimidazole-2-thiol; mp 181.8° C.

1. temperaturerefluxed for 20 hours
2. customThe reaction mixture is evaporated
3. additionwater is added to the residue
4. filtrationThe precipitated product is filtered off
5. washwashed with water
6. dissolutiondissolved in trichloromethane
7. customThe solution is dried
8. filtrationfiltered
9. customevaporated
10. customThe residue is crystallized from 4-methyl-2-pentanone