Ammonium Acetate → HCID 20443937, compound

Participants

Reaction Steps

A mixture of 2.92 g (0.01 mole) of the appropriate pyridinium salt, 2.26 g (0.01 mole) of β-(2-naphthoyl)acrylic acid and 8.5 g of ammonium acetate in 20 ml of methanol is heated at reflux for 6 hr. The mixture is concentrated and the residue is diluted with water and extracted with methylene chloride. The organic layer is concentrated and the residue is chromatographed on silica gel using 5% methanol-1% acetic acid-94% methylene chloride. The product is recrystallized from ethanol yielding 1.14 g (33.6%) of the titled crystals with a melting point of 272°-274° C. The C:H:N ratio is 81.32:5.01:4.16.

Provenance & Evidence