Ethylene Oxide → HCID 54110719, compound

Participants

Reaction Steps

26.4 g of ethylene oxide are introduced into 82.5 g of 4-(5-methyl-1-phenyl-3-hexyl)-1,2,4-triazolidine-3,5-dione (starting material 9) and 0.3 g of trimethyl benzyl ammonium hydroxide in 150 g of dimethyl acetamide. The solvent is distilled off in vacuo, the residue is dissolved by heating in 150 ml of ethyl acetate, 10 g of powdered active carbon are added and the whole is filtered hot. A deposit crystallises out on cooling and is isolated by filtration under suction and dried, giving 68 g of 1,2-bis-(2-hydroxyethyl)-4-(5-methyl-1-phenyl-3-hexyl)-1,2,4-triazolidine-3,5-dione in the form of colourless crystals melting at 114° C. IR- and NMR-spectra together with elemental analysis confirm the assumed structure.

Provenance & Evidence