反应详情

6.7 g. of 8-(5-Nitro-2-oxo-benzoxazolin-3-yl)-caprylic acid methyl ester are dissolved in 100 cc. of methanol and the solution is heated to boiling. 20 cc. of water are added to the solution and within 1 hour 13.9 g. of sodium dithionite are added and the mixture is boiled so long until the starting yellow solution is decolourized. Thereafter, the solution is evaporated in a vacuum, the residue is stirred with dilute soda lye and the solid crude product as filtered off with suction. The crude product is washed with water, dried and further purified chromatographically on silicic acid using hexane/ethyl acetate as eluant.

1. customThereafter, the solution is evaporated in a vacuum
2. additionwith dilute soda lye
3. filtrationthe solid crude product as filtered off with suction
4. washThe crude product is washed with water
5. customdried
6. customfurther purified chromatographically on silicic acid