HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 8-(6-Methyl-2-oxo-benzoxazolin-3-yl)-caprylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-methyl-1,3-benzoxazol-2(3H)-one | HCID 322634 | — |
| Reactant | Methyl 8-bromooctanoate | HCID 11107373 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-(6-Methyl-2-oxo-benzoxazolin-3-yl)-caprylic acid methyl ester | HCID 54132778 | — |
Reaction Steps
The product is produced as described in example 1 from 3.6 g. of NaH (of 80% suspension in mineral oil), 19.9 g. of 6-methylbenzoxazolin-2-one (produced in usual manners by subjecting 2-amino-5-methyl-phenol-hydrochloride to reaction with phosgene), 240 cc. of DMF, 28.4 g. of 8-bromo caprylic acid methyl ester and 3.6 g. NaJ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377695 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-5deb0d187efb4ec6b279fee92c0f5b74 |
| Source note | uspto-grants-1983_03 |