HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 7-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-enanthic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl- | HCID 84657 | — |
| Reactant | Ethyl 7-chloroheptanoate | HCID 529988 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-enanthic acid ethyl ester | HCID 54304288 | — |
Reaction Steps
The product is produced as described in example 1 from 1.9 g. of NaH (80% suspension in mineral oil), 13.2 g. of 1-phenylbenzimidazolin-2-one (produced in usual manner by subjecting N-phenyl-o-phenylenediamine to reaction with phosgene), 120 cc. of DMF, 12.1 g. of 7-chloroenanthic acid ethyl ester and 1.9 g. of NaJ. Eluant in chromatographic purification: hexane/ethylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377695 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-5de6ee76530c498fbd32795bab90ea10 |
| Source note | uspto-grants-1983_03 |