HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 8-[2-Oxo-3-(3-trifluoromethylbenzyl)-benzimidazolin-1-yl]-caprylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(Trifluoromethyl)benzyl chloride | HCID 69716 | — |
| Reactant | 8-(2-Oxobenzimidazolin-1-yl)-caprylic acid methyl ester | HCID 12961171 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-[2-Oxo-3-(3-trifluoromethylbenzyl)-benzimidazolin-1-yl]-caprylic acid methyl ester | HCID 54260101 | — |
Reaction Steps
The product is produced as described in example 1 from 0.72 g. of NaH (80% suspension in mineral oil), 7 g. of 8-(2-oxo-benzimidazolin-1-yl)-caprylic acid methyl ester, 100 cc. of DMF, 4.7 g. of 3-trifluoromethylbenzylchloride and 0.72 g. of NaJ. Eluant for chromatographic purification: hexane/ethylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377695 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-ec257a1781bc48dc815f712c9b51ca41 |
| Source note | uspto-grants-1983_03 |