Thionyl Chloride → HCID 53703385, compound

Participants

Reaction Steps

5 cc. of thionylchloride are added to 1 g. of 8-(2-oxo-3-phenyl-benzimidazolin-1-yl)-caprylic acid and the mixture is stirred at room temperature for 2 hours. Unreacted thionylchloride is evaporated in a vacuum, the residue is dissolved in a small amount of anhydrous chloroform and 238 mg. of hexanol are added to the solution. The mixture is stirred at room temperature for 4 hours, consequetively washed with 5% NaHCO3 solution and water, dried over Na2SO4 and evaporated in a vacuum. The residue is further purified chromatographically on silicic acid gel using hexane/ethyl acetate as eluant.

Provenance & Evidence