4'-Hydroxypropiophenone → Ifenprodil hydrobromide

Participants

Reaction Steps

To 4 ml of dioxane were added 6.0 g of 4'-hydroxypropiophenone. 6.4 Grams of bromine were added dropwise to the mixture with stirring at room temperature, and the reaction liquid was stirred for an additional 5 minutes. To the reaction liquid were then added 7.5 g of 4-benzylpyridine, 100 ml of methanol and 2.0 g of potassium carbonate, and the mixture was refluxed under heating for 5 hours. The reaction mixture was then treated in the same manner as described in Example 26, whereby 12.2 g (75.0%) of ifenprodil hydrobromide were obtained as white crystals.

Provenance & Evidence