HCID 20505870, compound → HCID 54107525, compound

HRID 355147Notes

Reaction equation

HRID 355147 reaction equation
[N:1]1([C:7]2[C:15]([F:16])=[CH:14][C:13]([S:17]([N:20]3[CH2:25][C@H:24]([CH3:26])[CH2:23][C@H:22]([CH3:27])[CH2:21]3)(=[O:19])=[O:18])=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])[CH2:6][CH2:5]C[CH2:3][CH2:2]1.N1(C2C(F)=CC(S(N3CCOCC3)(=O)=O)=CC=2C(O)=O)CCCCC1.C(N(CCCC)C1C(Cl)=CC(S(N2C[C@H](C)C[C@H](C)C2)(=O)=O)=CC=1C(O)=O)CCC.N1(C2C(Cl)=CC(S(N(CC)CC)(=O)=O)=CC=2C(O)=O)CCCCC1.N1(C2C(C)=CC(S(NC3C=CC=CC=3)(=O)=O)=CC=2C(O)=O)CCCCC1.C(N(C1C(C(F)(F)F)=CC(S(N2C[C@H](C)C[C@H](C)C2)(=O)=O)=CC=1C(O)=O)CCC)C.C(N(CC)C1C=C(F)C(S(NCCCC2C=CC(Br)=CC=2)(=O)=O)=CC=1C(O)=O)C.N1(C2C=C(Cl)C(S(NC3C=CC=C(Cl)C=3)(=O)=O)=CC=2C(O)=O)CCCCC1.C(N(C(C)C)C1C=C(C)C(S(N2CCCCC2)(=O)=O)=CC=1C(O)=O)(C)C.N1(C2C=CC(S(NC3C=CC(Cl)=C(Cl)C=3)(=O)=O)=C(F)C=2C(O)=O)CCCCC1.C(N(CC)C1C=CC(S(N2CCOCC2)(=O)=O)=C(F)C=1C(O)=O)C.N1(C2C=CC(S(N3CCC(C)(C)CC3)(=O)=O)=C(F)C=2C(O)=O)CCCCC1.C(N(CCC)C1C=CC(S(N(CCCC)C2C=CC(Cl)=C(Cl)C=2)(=O)=O)=C(F)C=1C(O)=O)CC.N1(C2C=CC(S(N(CCCC)C3C=CC(Cl)=C(Cl)C=3)(=O)=O)=C(F)C=2C(O)=O)CCCCC1>>[CH2:6]([N:1]([CH2:2][CH3:3])[C:7]1[C:15]([F:16])=[CH:14][C:13]([S:17]([N:20]2[CH2:25][C@H:24]([CH3:26])[CH2:23][C@H:22]([CH3:27])[CH2:21]2)(=[O:18])=[O:19])=[CH:12][C:8]=1[C:9]([OH:11])=[O:10])[CH3:5]

Participants

15

Reactant 14

HCID 20505870HCID 20505870, compoundHCID 20505897HCID 20505897, compoundHCID 20505926HCID 20505926, compoundHCID 20505928HCID 20505928, compoundHCID 20505932HCID 20505932, compoundHCID 20505985HCID 20505985, compoundHCID 20505993HCID 20505993, compoundHCID 20506020HCID 20506020, compoundHCID 20506051HCID 20506051, compoundHCID 20506129HCID 20506129, compoundHCID 53815080HCID 53815080, compoundHCID 54209479HCID 54209479, compoundHCID 54228215HCID 54228215, compoundHCID 57194179HCID 57194179, compound

Product 1

HCID 54107525HCID 54107525, compound

Procedure

2-piperidino-3-fluoro-5-(cis-3,5-dimethylpiperidinosulfonyl)benzoic acid; 2-piperidino-3-fluoro-5-morpholinosulfonylbenzoic acid; 2-hexamethyleneimino-3-fluoro-5-morpholinosulfonylbenzoic acid; 2-di-n-butylamino-3-chloro-5-(cis-3,5-dimethylpiperidinosulfonyl)benzoic acid; 2-piperidino-3-chloro-5-diethylaminosulfonylbenzoic acid; 2-piperidino-3-methyl-5-phenylaminosulfonylbenzoic acid; 2-hexamethyleneimino-3-chloro-5-piperidinosulfonylbenzoic acid; 2-(N-ethyl-N-n-propylamino)-3-trifluoromethyl-5-(cis-3,5-dimethylpiperidinosulfonyl)benzoic acid; 2-diethylamino-4-fluoro-5-(3-p-bromophenylpropylaminosulfonyl)benzoic acid; 2-piperidino-4-chloro-5-(3-chlorophenylaminosulfonyl)benzoic acid; 2-hexamethyleneimino-4-chloro-5-hexamethyleneiminosulfonylbenzoic acid; 2-di-i-propylamino-4-methyl-5-piperidinosulfonylbenzoic acid; 2-di-n-butylamino-4-methoxy-5-hexamethyleneiminosulfonylbenzoic acid; 2-piperidino-6-fluoro-5-(3,4-dichlorophenylaminosulfonyl)benzoic acid; 2-diethylamino-6-fluoro-5-morpholinosulfonylbenzoic acid; 2-piperidino-6-fluoro-5-(4,4-dimethylpiperidinosulfonyl)benzoic acid; 2-diethylamino-3-fluoro-5-(N-methyl-N-[2-p-chlorophenethyl]aminosulfonyl)benzoic acid; 2-piperidino-3-fluoro-5-(N-ethyl-N-[2-p-chlorophenethyl]aminosulfonyl)benzoic acid; 2-hexamethyleneimino-3-methyl-5-(N-methyl-N-phenylaminosulfonyl)benzoic acid; 2-di-n-propylamino-6-fluoro-5-(N-n-butyl-N-[3,4-dichlorophenyl]aminosulfonyl)benzoic acid; and 2-piperidino-6-fluoro-5-(N-n-butyl-N-[3,4-dichlorophenyl]aminosulfonyl)benzoic acid.

Sources & evidence

ORD record
ord-bb7aefcc62a9410a8008525608d741bf
Source dataset
uspto-grants-1983_03
Patent number
US04377521

Reaction notes

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