1-Methyl-6-nitro-1H-indole → HCID 20442744, compound

HRID 355160Notes

Reaction equation

HRID 355160 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([F:17])=[CH:14][CH:15]=2)[C:10]([C:18](=[O:26])[C:19]([Cl:25])=[C:20]([Cl:24])[C:21]([OH:23])=O)=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:27][N:28]1[C:36]2[C:31](=[CH:32][CH:33]=[C:34]([N+:37]([O-:39])=[O:38])[CH:35]=2)[CH:30]=[CH:29]1>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([F:17])=[CH:14][CH:15]=2)[C:10]([C:18]2([C:30]3[C:31]4[C:36](=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=4)[N:28]([CH3:27])[CH:29]=3)[O:26][C:21](=[O:23])[C:20]([Cl:24])=[C:19]2[Cl:25])=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 106073591-Methyl-6-nitro-1H-indoleHCID 542890844-(1-Benzyl-5-fluoro-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid

Product 1

HCID 20442744HCID 20442744, compound

Procedure

Following a procedure similar to that described above in part B of this example by using 4-(1-benzyl-5-fluoro-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid instead of 4-(1,2-dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid and 1-methyl-6-nitroindole in place of 1,2-dimethylindole, there is obtained 5-(1-benzyl-5-fluoro-3-indolyl)-5-(1-methyl-6-nitro-3-indolyl)-3,4-dichloro-2(5H)-furanone (Formula V: R=C6H5CH2 ; R1 =R3 =H; R2 =CH3 ; Y=6-F; Y1 =6-NO2).

Sources & evidence

ORD record
ord-a0c02c00e3d3449ea71895c4baf0d548
Source dataset
uspto-grants-1983_03
Patent number
US04377698

Reaction notes

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