HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Dibenzyl L-aspartate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | L-Aspartic acid, 1,4-bis(phenylmethyl) ester, 4-methylbenzenesulfonate (1:1) | HCID 2808531 | — |
| Solvent | Water | HCID 962 | — |
| Product | Dibenzyl L-aspartate | HCID 2808532 | 100.5% |
Reaction Steps
A mixture of dibenzyl (S)-aspartate p-toluenesulfonic acid salt (48.6 g, 0.1 mole), diethylether (300 ml), water (100 ml), and saturated aqueous potassium carbonate (50 ml) is shaken vigorously. The layers are separated and the aqueous portion is extracted with more ether (2×100 ml). The combined ethereal extracts are washed with brine, dried with magnesium sulfate, filtered, and evaporated under vacuum to afford dibenzyl (S)-aspartate (31.5 g) as a water white liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04378315 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-870acc776a25494e883ab1e2aeeef4d2 |
| Source note | uspto-grants-1983_03 |