Formate → HCID 20214918, compound

Participants

Reaction Steps

15.5 gm of 1-{-[2-hydroxy-2-(4-benzyloxy-phenyl)benzylethylamino]-propyl}-1,2,3,4-tetrahydro-4-quinazolone (m.p. 119°-121° C.) were dissolved in 250 ml of methanol and debenzylated by hydrogenation at 60° C. and 6 bars pressure in the presence of palladium as the catalyst. After 2 mols of hydrogen had been taken up, the hydrogenation was complete, yielding of 8 gm of 1-{3-[2-hydroxy-2-(4-hydroxyphenyl)ethylamino]-propyl}-1,2,3,4-tetrahydro-4-quinazolone, whose formate of the formula ##STR75## had a melting point of 174°-176° C. The yield was 61.5% of theory.

Provenance & Evidence