Oxalyl chloride → p-Nitrobenzyl 2-(4-Acetylthio-2-oxo-1-azetidinyl)-2-chloroacetate

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Reaction Steps

To a mixture of acid 1 (10.0 g, 79 mmoles) in 100 ml of oxalyl chloride was added one drop of dimethylformamide. The mixture was stirred for 1.15 h at 23° and then the excess oxalyl chloride was distilled off at 23° and 10-20 torr to give acid chloride 2 as a brown oil, 11.4 (100%). ##STR182##

Provenance & Evidence