Triethylamine → HCID 86738831, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (ice-salt) stirred solution of 3-hydroxymethyl-4-triphenylmethylthio-2-azetidinone (1.76 g 4.7 mmol) in CH2Cl2 (10 ml) and triethylamine (2.6 g, 25 mmol) was added dropwise formic-acetic acid anhydride (1.76 g, 20 mmol). The mixture was stirred 20 min at -10° C. and 20 min at room temperature, followed by partition between water and CH2Cl2. Drying and concentration of organic phase gave an oil which crystallized from ether to give 1.7 g (94.4%) of the title compound as white solid, mp 143°-144° C.; 1Hmr (CDCl3) δ: 7.98 (1H, formyl) 7.3 (15H, s), 4.82 (1H, 4-H), 4.25 (2H, d, J=9 Hz) and 3.37 ppm (1H, m); ir (nujol) νmax : 1723, 1763, 1776 cm-1. ##STR832##

Provenance & Evidence