Thionyl Chloride → HCID 20505475, compound

Participants

Reaction Steps

A mixture of crude 4-azidopentanoic acid (8.0 g, 56 mmol) and thionyl chloride (10 g, 84 mmol) was heated at 40°-45° C. for 1.5 h, followed by evaporation of excess thionylchloride in vacuo. The residual oil was distilled to give 6.8 g (75%) of the title compound, bp 60°-65° C./0.3 mm: 1Hmr (CDCl3) δ: 3.55 (1H, q, J=13 Hz), 3.03 (2H, t, J=13 Hz), 1.9 (2H, t, J=13 Hz and 1.3 ppm (3H, d, J=13 Hz); ir (neat νmax : 2100, 1792 cm-1.

Provenance & Evidence