Ethanol → HCID 54011110, compound

Participants

Reaction Steps

72 mg of palladium-carbon (palladium=about 5%), 372 mg (0.73 mM) of (S)-4,6-dichloro-(5-3-fluorononyl)-2-(4-decylphenyl)pyrimidine, 5 ml of 99%-ethanol, 118 mg (2.92 mM) of magnesium oxide and 0.3 ml of distilled water were placed in a two-necked round-bottomed flask and subjected to hydrogen addition for 5 hours at 60° C. After the reaction, benzene was added to the reaction mixture and the catalyst as removed from the reaction mixture, followed by distilling-off of the solvent and purification by thin-layer chromatography (eluent: benzene; Rf=0.5) to obtain 222 mg (0.50 mM) of (S)-5-(3-fluorononyl)-2-(4-decylphenyl)pyrimidine (crude product). The crude product was recrystallized from hexane to obtain an objective product (Yield: 69.2%).

Provenance & Evidence