Neopentyl alcohol → HCID 22118163, compound

Participants

Reaction Steps

2,6-dinitromandelic acid (4.00 g, 16.5 mmol) was added to an excess of neopentyl alcohol (20.0 g, 227 mmol) melted in a round bottom flask. To this solution was added 5 drops of H2SO4 and it was heated to reflux for 3 hours. The excess neopentyl alcohol was removed under reduced pressure, and the residue was purified by column chromatography over silica gel (60-200 mesh) using methylene chloride/hexane (1:1) as the eluant. The yield after two recrystallizations from CHCl3 /petroleum ether was 3.8 g (74%).

Provenance & Evidence