HuagongsheHuagongshe Chemistry Print Report · For research reference only
DL-beta-Phenylalanine → HCID 11833969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | DL-beta-Phenylalanine | HCID 69189 | — |
| Reactant | HCID 69946905 | HCID 69946905 | — |
| Product | HCID 11833969 | HCID 11833969 | — |
| Product | Methyl (3S)-3-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoate | HCID 71751629 | — |
Reaction Steps
Methyl-β-[[(phenylmethoxy)carbonyl]amino]-benzenepropanoate (4.87 g), prepared from 3-amino-3-phenylpropionic acid via standard methods, is separated by chiral HPLC [(R,R)-Whelk-O 1 column, elution with 40% isopropyl alcohol in hexane) to give 2.20 g of methyl (S)-β-[[(phenylmethoxy)carbonyl]amino]benzenepropanoate and 2.33 g methyl (R)-β-[[(phenylmethoxy)carbonyl]amino]benzenepropanoate. Each enantiomer is analyzed at >99% ee. Data for (S)-configuration enantiomer
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05830869 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-3c416f01f6aa4ad4aba447933c6cc44b |
| Source note | uspto-grants-1998_11 |