Sodium Hydroxide → HCID 1587547, compound

Participants

Reaction Steps

A solution of (S)-β-[[(phenylmethoxy)carbonyl]amino]-benzenepropanoate (1.60 g, 5.11 mmol), 1 M NaOH (25 mL) and THF (25 mL) is stirred 18 hours at ambient temperature. The reaction is concentrated in vacuo to remove THF, the residue diluted with 30 mL H2O, and washed with (3×25 mL) Et2O. The aqueous phase is brought to pH=3 with concentration. HCl and the resulting precipitate collected and dried to afford 1.40 g (4.69 mmol, 92%) product as a white solid. mp 135° C.

Provenance & Evidence