Hydrochloric Acid → HCID 54012151, compound

Participants

Reaction Steps

221 mg of the methyl ester from Step 1 are hydrolyzed by treatment with 5 mL of 1N KOH and 5 mL of MeOH for 4 hours at room temperature. The solution is made acidic with 1N HCl. Most of the MeOH is removed and the product is extracted into EtOAC. The product is purified by flash chromatography on silica gel using 70% hexanes/28% EtOAc/2% HOAc to give the title compound.

Provenance & Evidence